drug: fluoxetine

• Clinical class: antidepressant
• Chemical class: phenylpropylamine derivative
• Active metabolite: norfluoxetine
• Action: selective serotonin reuptake inhibitor
• CSA schedule: none
• DEA number: none
• MEDLINEplus^® Drug Information

U.S. Preparations:

• fluoxetine HCl Oral Solution (Apotex)
• Prozac^® (Lilly) FDA approved for treatment of:
  12.31.1987 depression
  4.1.1993 obsessive compulsive disorder
  12.31.1996 bulimia nervosa
  1.3.2003 Major Depressive Disorder (MDD) and Obsessive Compulsive Disorder (OCD) in the pediatric population (7-17 years old)
  U.S. Prescribing Information
• Prozac^® Weekly (Lilly) FDA approved:
  2.27.2001 for treatment of depression
  U.S. Prescribing Information
• Sarafem™ (Lilly) FDA approved:
  7.6.2000 in the treatment of premenstrual dysphoric disorder (PMDD)
  6.12.2002 in the treatment of premenstrual dysphoric disorder (PMDD), using an intermittent dosing regimen, as an alternative to the currently approved continuous dosing regimen
  U.S. Prescribing Information

Combination with olanzapine

• Symbyax™

Preparations Outside U.S.:

• Auscap, Adofen, Bioxetin, Deprenon, Deprex, Dinalexin, Erocap, Exostrept, Felicium, Flonital, Fluctin, Fluctine, Fluocim, Fluohexal, Fluoxeren, Fluoxifar, Fluoxin, Flutin, Fluval, Fluxadir, Fluxonil, Fondur, Fontex, Fonzac, Ladose, Lorien, Lovan, Mutan, Nicoflox, Nycoflox, Orthon, Portal, Prodep, Prozyn, Reneuron, Sanzur, Sartuzin, Serol, Seronil, Stephadilat, Tingus, Zactin

Stephen Stahl's Clinical Pearls* (Consult your physician before making any change in your treatment.)

• Consider for atypical depression.
• Consider avoiding for agitated insomniacs who wish to avoid sexual dysfunction.
• FDA label for depression, OCD and (almost) for bulimia.
• Not as well tolerated without cotherapy for panic.
• Long half life; even longer lasting active metabolite.
• Less selective over norepinephrine and 5HT2C.
• Inhibits 2D6.

• Glenmullen, Joseph Prozac Backlash - Overcoming the Dangers of Prozac, Zoloft, Paxil, and Other Antidepressants with Safe, Effective Alternatives Hardcover 2000
• Kramer, Peter D: Listening to Prozac Paperback 1997 | Audio Cassettes 1994
• Prozac Nation DVD Christina Ricci, Anne Heche 2001

*Reprinted with permission from: Stahl, Stephen M Psychopharmacology of Antidepressants Paperback 1997 Martin Dunitz, Ltd & Blackwell Science You cannot fully appreciate this book until you have seen the extraordinary illustrations of every aspect of this area of psychopharmacology and neurochemistry. Loaded with practical clinical "pearls."

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