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drug: fluoxetine

Clinical class: antidepressant
Chemical class: phenylpropylamine derivative
Active metabolite: norfluoxetine
Action: selective serotonin reuptake inhibitor
CSA schedule: none
DEA number: none
MEDLINEplus^® Drug Information

U.S. Preparations:

fluoxetine HCl Oral Solution (Apotex)
Prozac^® (Lilly) FDA approved for treatment of:
12.31.1987 depression
4.1.1993 obsessive compulsive disorder
12.31.1996 bulimia nervosa
1.3.2003 Major Depressive Disorder (MDD) and Obsessive Compulsive Disorder (OCD) in the pediatric population (7-17 years old)
U.S. Prescribing Information
Prozac^® Weekly (Lilly) FDA approved:
2.27.2001 for treatment of depression
U.S. Prescribing Information
Sarafem™ (Lilly) FDA approved:
7.6.2000 in the treatment of premenstrual dysphoric disorder (PMDD)
6.12.2002 in the treatment of premenstrual dysphoric disorder (PMDD), using an intermittent dosing regimen, as an alternative to the currently approved continuous dosing regimen
U.S. Prescribing Information

Combination with olanzapine

Symbyax™

Preparations Outside U.S.:

Auscap, Adofen, Bioxetin, Deprenon, Deprex, Dinalexin, Erocap, Exostrept, Felicium, Flonital, Fluctin, Fluctine, Fluocim, Fluohexal, Fluoxeren, Fluoxifar, Fluoxin, Flutin, Fluval, Fluxadir, Fluxonil, Fondur, Fontex, Fonzac, Ladose, Lorien, Lovan, Mutan, Nicoflox, Nycoflox, Orthon, Portal, Prodep, Prozyn, Reneuron, Sanzur, Sartuzin, Serol, Seronil, Stephadilat, Tingus, Zactin

Stephen Stahl's Clinical Pearls* (Consult your physician before making any change in your treatment.)

Consider for atypical depression.
Consider avoiding for agitated insomniacs who wish to avoid sexual dysfunction.
FDA label for depression, OCD and (almost) for bulimia.
Not as well tolerated without cotherapy for panic.
Long half life; even longer lasting active metabolite.
Less selective over norepinephrine and 5HT2C.
Inhibits 2D6.

Books and Other Media:
Follow the hypertext link to purchase items.

Fetching Cody Barclay Hope, Jim Byrnes, Jay Baruchel, and Chilton Crane 2005
Glenmullen, Joseph Prozac Backlash - Overcoming the Dangers of Prozac, Zoloft, Paxil, and Other Antidepressants with Safe, Effective Alternatives Hardcover 2000
Kramer, Peter D: Listening to Prozac Paperback 1997 | Audio Cassettes 1994
Prozac Nation Christina Ricci, Anne Heche 2001

*Reprinted with permission from: Stahl, Stephen M Psychopharmacology of Antidepressants Paperback 1997 Martin Dunitz, Ltd & Blackwell Science You cannot fully appreciate this book until you have seen the extraordinary illustrations of every aspect of this area of psychopharmacology and neurochemistry. Loaded with practical clinical "pearls."

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