drug: olanzapine
 *
U.S. Preparations:
Combination with fluoxetine
Preparations Outside U.S.:
Stephen Stahl's Clinical Pearls* (Consult your physician before making any change in
your treatment.)
- Well accepted for use in schizophrenia and bipolar disorders, including difficult cases
- Many anecdotal reports of use in children and treatment-refractory cases, and for
positive symptoms of psychosis in disorders
other than schizophrenia
- Documented efficacy as augmenting agent
to SSRIs in non-psychotic, treatment-resistant, major depressive disorders
- Muscarinic antagonist properties
theoretically unfavorable for cognition in schizophrenia, and in elderly people, but
cognitive symptoms of schizophrenia may improve in some clinical trials.
- Same as placebo does not mean never, although EPS
unusual at low to mid doses.
- More weight gain than with other anti-psychotics; this does not mean that every patient
gains weight.
- Not necessary to monitor liver function tests except in significant liver disease
Books and Other
Media:
Follow the hypertext link to purchase items. |
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- Wyden, Peter Conquering
Schizophrenia - A Father, His Son, and A Medical Breakthrough This book
by Peter Wyden (1977) tells of the twenty five years that the author's son struggled with
schizophrenia. It documents how he was hospitalized numerous times and of the many, many psychiatrists, clinics and group homes he
was involved with. It also tells of the various medications taken, the shock treatments, and even the hypnosis tried. It then explains
that he was put on olanzapine and in his father's words, "Jeff was
like a civilian!" His mind was opening and even though there is no cure now there is
home. It's a good book and full of solid information. - W/AMI
*Reprinted with permission from: Stahl, Stephen M Psychopharmacology
of Antipsychotics Paperback 1999 Martin Dunitz, Ltd
You cannot fully appreciate this book until you have seen the extraordinary
illustrations of every aspect of this area of psychopharmacology and
neurochemistry. Loaded with practical clinical "pearls."
*Molecule graphic courtesy of
Steve Chapman
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