The question I found myself asking: What defined the conflict between these two sisters? Was it Sadie's substance abuse or personality clash? Did birth order or family emotional process contribute? Does Sadie have a personality disorder? If so, which one?
While generally we cannot tell which drug or combination a character has used, in one scene Sadie and Jasmine, both intoxicated, lie in bed next to a table with a syringe. Jasmine mentions detox and says, "Don't touch my 'wake up'," apparently referring to the dose, presumably of heroin, he has prepared for morning (1:29).
Sadie appears to be withdrawing from heroin in an airport (1:31) where she waits for a flight to a hospital for detox. At the hospital, presumably a rehabilitation facility, a nurse explains she will give Sadie "Valium" as well as clonidine (mispronounced) patches "for the heroin" (1:35).