The Substance

Injection of an egg yolk (0:01)

By telephone, television producer Harvey asks someone, referring to film star Elisabeth Sparkle, "... for King Kong?" (0:06)

Harvey: "George, those ratings are insane." (0:09)

Fred asks Elisabeth, "... now that we’re reconnected?" (0:12)

Voice on video: "Have you ever dreamt of a better version of yourself?... One single injection..." (0:14)

Label: "OTHER SELF" 
Label: ”FOOD OTHER SELF” (0:22)

Elisabeth injects herself. (0:25)

New self injects herself with fluid withdrawn from old self.
Injections repeat throughout the film. (0:35)

Sticky note: "Too drunk to take the bike..." (1:01)

By telephone, Elisabeth tells a man, referring to Sue (new self), "... obviously she was drunk." (1:03)

Neighbor Oliver tells Elisabeth, "... don’t be shy..." (1:05)

The old man tells Elisabeth, "I was just curious..." (1:08)

By telephone, Fred tells Elisabeth, "Sorry, I’m in shock." 
”Sorry, I’m in shock again...” (1:10)

Sue: "... I just got distracted." (1:17)

Sue appears to awaken from a nightmare. (1:19)

By telephone, Elisabeth tells someone, referring to Sue, "... She’s a selfish bitch." (1:24)

Sue, on a talk show: "... it has always been my dream to be on the screen." 
Elisabeth: ”This is my dream.” 
”... to be sincere and grateful...” (1:29)

Elisabeth bangs her head on the floor repeatedly. (1:32)

Sue’s date: "Stressed out about tomorrow?" 
”You a little cranky...?” (1:37)

Elisabeth starts to inject Sue, but removes the needle.
Elisabeth tells Sue, ”... I hate myself...” 
Elisabeth strikes Sue on the head with a vase. 
Sue shoves Elisabeth so that Elisabeth’s head strikes a cabinet. 
Sue slams Elisabeth’s head against the mirror repeatedly.
Sue continues to beat Elisabeth. (1:42)

Man’s voice: "Have you ever dreamt of a better version of yourself?..." (1:53)

Sue injects herself. (1:57)

Stagehand: "... We were starting to worry..." (2:03)